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Russian ‘Sputnik V’ rejected for potentially increasing HIV risk: Study

By Saima Siddiqui 
Updated Date
Russian ‘Sputnik V’ rejected for potentially increasing HIV risk: Study

Johannesburg: While the world is ramping up its vaccine programmes to counter Covid-19 pandemic by getting more and more of its populace jabbed against the deadly virus, South Africa’s rejection to Russia’s ‘Sputnik V’ coronavirus vaccine – flagging it potential to increase the risk of HIV infection among men – has raised concerns about the efficacy of these vaccines.

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Speaking to the media, the South African Health Product Regulatory Authority (SAHPRA) said that the use of the ‘Sputnik V’ vaccine in the country has been barred following an increase in the incidences and concerns that it may increase the risk of vaccinated males acquiring HIV.

The decision was based on earlier studies testing the safety of a modified form of adenovirus — a type of virus that causes respiratory infections — known as the Ad5 and contained in the Russian jab.

“Use of the Sputnik V vaccine in South Africa, a setting of a high HIV prevalence and incidence, may increase the risk of vaccinated males acquiring HIV,” the South African Health Product Regulatory Authority (SAHPRA) said in a statement.

It noted that the company behind the application for the use of Sputnik V in South Africa had no proof the formula would be safe “in settings of high HIV prevalence”.

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“The rolling review of the Sputnik V vaccine will, however, remain open for submission of relevant safety data in support of the application,” it added.

Russia’s Gamaleya Centre, which developed Sputnik V, said it would produce information to show that SAHPRA’s concerns were “completely unfounded”.

“Speculation regarding the association between adenovirus type-5 vectored vaccines and HIV transmission in high risk groups has been based on small-scale studies,” it said in a statement.    

South Africa, the country worst-hit by the pandemic in Africa, also has the world’s highest number of people living with HIV.

It has been struggling with vaccine hesitancy.

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Just over a quarter of 40 million targeted for vaccination by early 2022 are fully jabbed to date.

South Africa is this week set to begin vaccinating children as young as 12 and offering booster shots to certain immuno-compromised citizens.

It is currently offering the single-dose Johnson & Johnson — which also contains an adenovirus but of a different type — and the rMNA Pfizer/BioNTech jab.

The Chinese-made Sinovac has also been approved.

The World Health Organization has not yet given Sputnik V the green light for emergency use, although it is being administered in at least 45 countries. 

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