Ageing is one big factor people tend to run away from and they do not want to show their wrinkles by using ageing creams, tonics etc but it is also that one inevitable truth that everyone has to go through. Recently, according to the information given by a study, a drug has been invented to delay your ageing miraculously. Yes you read it right! Have ever heard of something that can even delay your ageing? Well yes it may sound weird but it is true on the other hand.
In the study, researchers from the University of Texas Medical Branch (UTMB) at Galveston identified a protein called Nicotinamide N-methyltransferase (NNMT) in muscle stem cells that appears to be responsible for the age-related dysfunction.
They developed a small molecule drug, NNMT inhibitor (NNMTi), which when prescribed to aged mice could limit NNMT’s effects as well as significantly increase muscle size, strength and metabolic state in the animals.
By resetting muscle stem cells to a more youthful state, the mice could be rejuvenated so that they could more effectively repair muscle tissues, the researchers explained.
“There are no treatments currently available to delay, arrest or reverse age-related muscle degeneration,” said Harshini Neelakantan, research scientist at UTMB.
“These initial results support the development of an innovative drug treatment that has the potential to help the elderly to become fitter, faster and stronger, thus enabling them to live more active and independent lives as they age,” she added.
For the study, published in Biochemical Pharmacology, the team treated ageing mice, suffering from muscle injury, with the drug or a placebo.
Following seven days of treatment, researchers saw that the aged mice, which received the drug, had more functional muscle stem cells than the placebo mice.
Moreover, the size of the muscle fibres doubled and the strength also increased significantly.
Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice.